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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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Data corrente: |
25/01/2024 |
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Data da última atualização: |
11/04/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C. |
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Afiliação: |
LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS. |
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Título: |
Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 327, Apr. 2024, 110137. |
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Páginas: |
9 p. |
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DOI: |
10.1016/j.vetpar.2024.110137 |
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Idioma: |
Inglês |
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Conteúdo: |
The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. MenosThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer ... Mostrar Tudo |
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Palavras-Chave: |
Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol. |
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Thesagro: |
Bovino; Carrapato. |
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Thesaurus Nal: |
Rickettsia rickettsii. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02636naa a2200373 a 4500
001 2161314
005 2024-04-11
008 2024 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2024.110137$2DOI
100 1 $aANHOLETO, L. A.
245 $aAcaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.$h[electronic resource]
260 $c2024
300 $a9 p.
520 $aThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly.
650 $aRickettsia rickettsii
650 $aBovino
650 $aCarrapato
653 $aAcmella oleracea
653 $aBovine parasite sadness
653 $aBrazilian Spotted Fever
653 $aCattle tick
653 $aControl
653 $aNanoformulation
653 $aSpilanthol
700 1 $aBRANCAGLION, G. A.
700 1 $aSANTOS, D. M. DOS
700 1 $aKAPRITCHKOFF, R. T. I.
700 1 $aCASTRO, K. N. de C.
700 1 $aCANUTO, K. M.
700 1 $aRODRIGUES, R. A. F.
700 1 $aCORREA, D. S.
700 1 $aCHAGAS, A. C. de S.
700 1 $aPASTRE, J. C.
773 $tVeterinary Parasitology$gv. 327, Apr. 2024, 110137.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Registro Completo
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Biblioteca(s): |
Embrapa Florestas; Embrapa Mandioca e Fruticultura. |
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Data corrente: |
19/04/2010 |
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Data da última atualização: |
17/09/2019 |
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Tipo da produção científica: |
Folder/Folheto/Cartilha |
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Autoria: |
OLIVEIRA, L. A. de; GODOY, R. C. B. de. |
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Afiliação: |
LUCIANA ALVES DE OLIVEIRA, CNPMF; ROSSANA CATIE BUENO DE GODOY, CNPF. |
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Título: |
Chips de mandioca. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
Cruz das Almas: Embrapa Mandioca e Fruticultura Tropical, 2010. |
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Idioma: |
Português |
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Conteúdo: |
A mandioca (Manihot esculenta Crantz) é a base energética da alimentação em vários países tropicais e desempenha um importante papel no âmbito da agricultura familiar, principalmente no Nordeste. Contudo, um dos maiores obstáculos para a maior utilização da mandioca é a sua alta pereciblidade, pois quando armazenada em condições ambientais, possui vida útil muito restrita. Estima-se que 23% da produção de raízes de mandioca são perdidas após a colheita no Brasil, devido ao desconhecimento de técnicas adequadas de processamento e armazenamento. Dessa forma, o desenvolvimento de novas tecnologias de processamento dessas raízes, pode proporcionar a oferta de produtos de maior valor agregado, pouco perecíveis e de grande aceitação pelo mercado consumidor, a exemplo dos chips de mandioca. |
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Palavras-Chave: |
Chips. |
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Thesagro: |
Mandioca; Processamento. |
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Thesaurus NAL: |
cassava; Manihot. |
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Categoria do assunto: |
--
Q Alimentos e Nutrição Humana |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/86804/1/CHIPS-DE-MANDIOCAid26711.pdf
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Marc: |
LEADER 01266nam a2200181 a 4500
001 1696959
005 2019-09-17
008 2010 bl uuuu u0uu1 u #d
100 1 $aOLIVEIRA, L. A. de
245 $aChips de mandioca.
260 $aCruz das Almas: Embrapa Mandioca e Fruticultura Tropical$c2010
520 $aA mandioca (Manihot esculenta Crantz) é a base energética da alimentação em vários países tropicais e desempenha um importante papel no âmbito da agricultura familiar, principalmente no Nordeste. Contudo, um dos maiores obstáculos para a maior utilização da mandioca é a sua alta pereciblidade, pois quando armazenada em condições ambientais, possui vida útil muito restrita. Estima-se que 23% da produção de raízes de mandioca são perdidas após a colheita no Brasil, devido ao desconhecimento de técnicas adequadas de processamento e armazenamento. Dessa forma, o desenvolvimento de novas tecnologias de processamento dessas raízes, pode proporcionar a oferta de produtos de maior valor agregado, pouco perecíveis e de grande aceitação pelo mercado consumidor, a exemplo dos chips de mandioca.
650 $acassava
650 $aManihot
650 $aMandioca
650 $aProcessamento
653 $aChips
700 1 $aGODOY, R. C. B. de
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Registro original: |
Embrapa Mandioca e Fruticultura (CNPMF) |
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ID |
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Fechar
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